关键词: 血清可溶性CD105, CC类趋化因子配体20, CC类趋化因子配体5, 肺癌, 根治术, 预后

Abstract: Objective To investigate the relationship between the levels of serum soluble CD105(S-CD105),CC chemokine ligand 20(CCL20) and CC chemokine ligand 5(CCL5) and the prognosis of patients with lung cancer surgery.Methods A total of 86 lung cancer patients who received radical mastectomy in our hospital from March 2018 to March 2019 and were followed up until March 2022 were selected as the research subjects,and were set up as the observation group.They were divided into a good prognosis group(n=54) and a poor prognosis group(n=32).During the same period,43 healthy subjects were selected as the control group.The levels of S-CD105,CCL20 and CCL5 were compared,and the recurrence rate,metastasis rate and mortality of different levels of S-CD105,CCL20 and CCL5 were observed;the binary logistic regression model was used to analyze the effect of SCD105,CCL20 and CCL5 on the prognosis of patients with lung cancer surgery;ROC curve pattern analysis of AUC value,sensitivity and specificity of S-CD105,CCL20 and CCL5 in predicting the prognosis of patients with lung cancer surgery.Results The SCD105[(4.55±0.86) ng/ml],CCL20[(71.97±13.69)ng/ml] and CCL5[(49.50±5.17)ng/ml] in the observation group were higher than those in the control group [(3.38±0.52) ng/ml,(53.52) ±7.52) ng/ml,(17.52±2.02) ng/ml](all P＜0.05).There was no significant difference in S-CD105,CCL20 and CCL5 between the two groups before surgery,30-d and 90-d after surgery(P＞0.05).At 180 days after operation,the S-CD105[(7.85±1.52) ng/ml],CCL20[(88.25±19.65) ng/ml] and CCL5[(54.74±6.96) ng/ml] in the poor prognosis group were higher than those in the good prognosis group [(5.01±1.05) ng/ml,(65.38±11.74) ng/ml,(43.02±4.11) ng/ml(all P＜0.05).The recurrence rate,metastasis rate and mortality rate of serum S-CD105,CCL20,CCL5 high expression group were higher than those of low expression group(P＜0.05).Binary Logistic regression analysis showed that the levels of SCD105,CCL20 and CCL5 were risk factors affecting the prognosis of patients with lung cancer surgery(P＜0.05).Kendall's tau-b correlation analysis showed that SCD105,CCL20,and CCL5 were negatively correlated with the prognosis of patients with lung cancer surgery(r=-0.606,-0.437,-0.619,P＜0.05).ROC curve analysis showed that the AUC values of serum SCD105,CCL20,and CCL5 for predicting poor prognosis in patients with lung cancer surgery were 0.937,0.817,0.949(P＜0.05);the sensitivities were 90.60%,50.00%,and 93.80%,respectively;the specificities were 92.60%,100.00%,92.60%.Conclusion Serum levels of S-CD105,CCL20,and CCL5 are highly expressed in lung cancer patients,and their levels will change with postoperative recurrence or metastasis.Dynamic monitoring of their changes is helpful to provide an important reference for prognosis evaluation.

Key words: serum soluble CD105, CC chemokine ligand 20, CC chemokine ligand 5, lung cancer, radical resection, prognosis