关键词: 甘氨酸甲基转移酶, 肺癌, 癌组织, 癌旁组织

Abstract: Objective To exlpore the expression and clinical of Glycine methyltransferase(Glycine N-methyltransferase,GNMT) in lung cancer and adjacent tissues.
Methods 140 patients' cancer and adjacent tissues were selected,RT - qPCR and Western blot method were used to detect GNMT mRNA and protein expression in these tissues.The correlation of GNMT expression with gender,age,smoking history,tumor size,lymph node metastasis,TNM stage and long-term survival rate was analyzed.
Results The GNMT mRNA and protein expression in cancer tissues was higher than that in cancerous tissue(P<0.05).There was no significant correlation among GNMT expression and gender,age,smoking history(P>0.05),but there was negative correlation among the tumor size,lymph node metastasis and TNM staging(P<0.05).GNMT expression was higher,the longer patients postoperative survival time.The median survival was 34 months in the patients with low GNMT expression,but the medium survival in the patients with high GNMT expression was 45 months.
Conclusion GNMT could suppress the development of lung cancer,the prognosis of patients with high expression of GNMT is better.

Key words: Glycine N-methyltransferase, lung cancer, cancer tissue, paracancerous tissue