关键词: 导管接触性溶栓, 肝移植术后, 早期肝动脉血栓形成

Abstract: Objective To explore the efficacy and safety of catheter-directed thrombolysis(CDT) for early hepatic artery thrombosis(EHAT) after liver transplantation.
Methods A retrospective analysis of the clinical data of 23 patients with EHAT after liver transplantation in our department from January 2009 to November 2019.
Results All patients received CDT treatment.The average operation time of CDT catheter operation was(78±24) min.The average time of thrombolytic therapy was(87.4±22.8) h.The average dosage of urokinase was(344.5±62.3) million U.After CDT treatment,19 cases of hepatic artery thrombosis were completely dissolved,and the effective rate of CDT treatment was 82.6%(19/23).During CDT treatment,2 cases of abdominal hemorrhage(<100ml) occurred in 2 cases,and no other related complications occurred.The average follow-up time(60.4±3.7) months.The hepatic arterial patency rates of 19 patients with hepatic artery thrombosis completely dissolved at 1 year,2 years and 5 years were 94.7%(18/19)，89.5%(17/19),79%(15/19).
Conclusion CDT is a safe,effective,and minimally invasive treatment.It plays an increasingly important role in the treatment and prognosis of patients with EHAT after liver transplantation.

Key words: catheter-directed thrombolysis, after liver transplantation, early hepatic artery thrombosis