腹腔镜前列腺癌根治术对前列腺癌病人的疗效及对转化生长因子-β1、转化生长因子-β3及前列腺特异性抗原水平的影响

doi:10.3969/j.issn.1005-6483.2020.04.023

摘要/Abstract

摘要： 目的探讨腹腔镜前列腺癌根治术对前列腺癌病人的疗效及对转化生长因子-β1（TGF-β1）、转化生长因子-β3（TGF-β3）及前列腺特异性抗原（PSA）水平的影响。方法 2017年10月～2018年10月收治的前列腺癌病人104例，根据治疗方式将其分成腹腔镜组与开放性组，每组各52例。开放性组予以开放性前列腺癌根治术治疗，腹腔镜组则予以腹腔镜前列腺癌根治术治疗。随访1年，比较两组生存率及治疗前1天和治疗后30天的TGF-β1、TGF-β3及PSA水平。结果腹腔镜组12个月的生存率为96.15%（50/52），开放性组为的84.62%（44/52），两组比较差异有统计学意义（P＜0.05）。两组术后血清TGF-β1、TGF-β3、T-PSA、F-PSA水平与术前比较，差异有统计学意义（P＜0.05），两组间比较，差异无统计学意义（P＞0.05）。腹腔镜组术后并发症发生率低于开放性组，差异有统计学意义（P＜0.05）。结论腹腔镜前列腺癌根治术治疗前列腺癌疗效显著，可改善TGF-β1、TGF-β3及PSA水平，降低术后并发症发生风险。

关键词: 前列腺癌, 腹腔镜前列腺癌根治术, 转化生长因子-β1, 转化生长因子-β3, 前列腺特异性抗原

Abstract: Objective To study the effect of laparoscopic radical prostatectomy on prostate cancer patients and to analyze the effects of TGF- β1，TGF- β3，and PSA levels. Methods From October 2017 to October 2018，104 cases of prostate cancer patients admitted to our hospital were retrospectively analyzed and divided into laparoscopic group and open group according to different treatment methods.Open radical prostatectomy was performed in the open group and laparoscopic radical prostatectomy was performed in the laparoscopic group.Follow-up for 1 year，the survival rate，TGF-β1，TGF-β3 and PSA levels and postoperative complications of the two groups were compared 30 days after surgery，1 day before treatment and 30 days after treatment，respectively. Results The 12-month survival rate of the laparoscopic group was 96.15%（50/52），higher than that of the open group of 84.62%（44/52）（P<0.05）.The serum levels of TGF-β1 and TGF- β3 in the two groups after operation were lower than the before operation（all P<0.05），but the difference between the two groups was not significant（P>0.05）.The serum t-psa and f-psa levels in the two groups after operation were lower than the before operation（all P<0.05），but the difference between the two groups was not significant（P>0.05）.The incidence of postoperative complications in the laparoscopic group was lower than the open group（P<0.05）. Conclusion Laparoscopic radical resection of prostate cancer has a significant effect on patients with prostate cancer，and can effectively improve the levels of TGF- 1，TGF- 3 and PSA，and reduce the risk of postoperative complications.It is worthy of clinical application.

Key words: prostate cancer, laparoscopic radical resection of prostate cancer, transforming growth factor β1, transforming growth factor β3, prostate specific antigen

刘大乐肖克峰刘岩峰刘增钦黄建生. 腹腔镜前列腺癌根治术对前列腺癌病人的疗效及对转化生长因子-β1、转化生长因子-β3及前列腺特异性抗原水平的影响[J]. 临床外科杂志, 2020, 28(4): 374-377.

LIU Dale, XAIO Kefeng, LIU Yanfeng, et al.. The effect of laparoscopic radical prostatectomy on patients with prostate cancer and its effects on TGF-β1，TGF-β3 and PSA levels[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(4): 374-377.

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