临床外科杂志 ›› 2019, Vol. 27 ›› Issue (12): 1099-1101.doi: 10.3969/j.issn.1005-6483.2019.12.027

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长链非编码RNA在胰腺癌转移中的研究进展

  

  1. 400038 重庆,陆军军医大学第一附属医院肝胆外科研究所(刘淞淞);中国科学院大学重庆医院肝胆胰外科研究所(王槐志)
  • 出版日期:2019-12-20 发布日期:2019-12-20

Advances in the study of long non-coding RNA in metastasis of pancreatic cancer

  1. Institute of Hepatobiliary Surgery,First Affiliated Hospital of The Army Military Medical University,Chongqing 400038,China
  • Online:2019-12-20 Published:2019-12-20

摘要: 胰腺癌侵袭程度高,初诊即有局部淋巴结和远处转移。长链非编码RNA(IncRNA)最初被认为是基因转录组的“噪音”而未受到重视。但随着研究的深入,学者们发现lncRNA在人类基因组普遍被转录且起着重要的调控作用,与肿瘤的发生发展及转移密切相关。胰腺癌中有大量的lncRNA表达失调,其根据自身的亚细胞定位和结构不同,在胰腺癌转移中参与不同的生物学调控,涉及到上皮间质转化(EMT),自噬,肿瘤代谢,关键驱动基因等多方面。研究lncRNA在肿瘤转移中的作用及其分子机制,有望为胰腺癌提供新的防治策略和新的治疗靶点。

关键词: 胰腺癌, 长链非编码RNA

Abstract: Pancreatic cancer has a high degree of invasion,and local lymph nodes and distant metastases are diagnosed at the first diagnosis.Long-chain non-coding RNAs(1ncRNAs)were originally thought to be the “noise” of the gene transcriptome and were not taken seriously.However,with the deepening of research,scholars have found that 1ncRNAsaregenerally transcribed in the human genome and play  important regulatory roles,which is closely related to tumor development and metastasis.There are a large number of dysregulated 1ncRNAs in pancreatic cancer,which play different biological regulation mechanisms in pancreatic cancer metastasis according to their subcellular localization and structure,involving EMT,autophagy,tumor metabolism,and key drive genes and many other aspects.Further research on the relationship between lncRNAs and tumor metastasis may provide new strategies for pancreatic cancer prevention,diagnosis and treatment.This article summarizes the recent advances in the study oflncRNA in pancreatic cancer metastasis.

Key words: pancreatic cancer, non-coding RNAs

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