关键词: 磷酸化tau蛋白, 创伤性脑损伤, 诊断效能

Abstract: Objective To explore the diagnostic efficiency of phospho-tau（P-tau）and phospho tau-total tau radio（P-tau/T-tau）for predicting death and prognosis situation within half a year in traumatic brain injury（TBI）patients.
Methods 90 TBI patients treated in our hospital from June 2017 to June 2019 were employed as research targets.Patients’ death situation and prognosis by Glasgow outcome score（GOS） in half a year of follow-up were recorded and thus all patients were divided into death group，survival group，good prognosis group and bad prognosis group.Using Logistic regression to analyse the related factors of death，analysing relation among P-tau，P-tau/T-tau within 6h of injury and GOS scores，constructing ROC curve to assess prediction efficiency of P-tau and P-tau/T-tauon TBI patients’ death and prognosis.
Results There were 86 cases were employed.The duration from onset of symptoms to admission，P-tau and P-tau/T-tauin the death group were higher than those in the survival group（P<0.05）；Both of P-tau and P-tau/T-tau were the risk factors of death（P＜0.05）；GOS score in good prognosis group was higher than that bad prognosis group，P-tau and P-tau/T-tau in good prognosis group were lower than that bad prognosis group（P<0.05）；P-tau and P-tau/T-tau were negatively correlated with GOS score（r=-0.773、-0.745，all P=0.000）；The AUC of P-tau and P-tau/T-tauto predict patients’ death and prognosis were 0.767 and 0.873，0.968 and 0.961，respectively.There were no significant difference respectively between both of them in sensitivity of predicting death（91.30% and 91.34%）and prognosis（94.11% and 91.24%，P>0.05）.
Conclusion P-tau and P-tau/T-tau can effectively predict TBI patients’ death situation and prognosis within half a year.

Key words: phospho tau, traumatic brain injury, diagnostic efficiency