临床外科杂志 ›› 2018, Vol. 26 ›› Issue (11): 814-817.doi: 10.3969/j.issn.10056483.2018.11.005

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大隐静脉高位结扎联合腔内激光闭合术和泡沫硬化剂注射治疗下肢静脉曲张的对比分析

  

  1. 200062 上海市普陀区中心医院血管外科
  • 收稿日期:2018-07-19 出版日期:2018-11-20 发布日期:2018-12-03
  • 通讯作者: 黄荣,Email:15900159818@163.com

High ligation of great saphenous vein combined with endovenous laser closure and foam sclerotherapy for chronic varicose veins of lower extremities:a comparative study

  1. Department of Vascular Surgery,Central Hospital of Shanghai Putuo District,Shanghai 200062,China
  • Received:2018-07-19 Online:2018-11-20 Published:2018-12-03

摘要: 目的   分析大隐静脉高位结扎联合腔内激光闭合术(EVLT)和泡沫硬化剂注射治疗下肢静脉曲张的临床疗效。方法 下肢静脉曲张病人80例,根据手术方式不同,分为研究组及对照组,每组各40例,研究组采用大隐静脉高位结扎+泡沫硬化剂+EVLT治疗,对照组采用大隐静脉高位结扎+EVLT治疗,比较两组病人的临床疗效。结果 研究组病人的手术时间、术中出血量、切口数目、住院时间、术后视觉模拟评分、住院费用及并发症发生率分别为(57.8±13.3)分钟,(9.6±2.5)ml,(3.6±1.2)个,(4.2±1.2)天,(6.4±1.4)分,(6820.4±610.4)元和5.0%,对照组分别为(44.5±14.5分钟,(15.3±4.2) ml,(7.9±2.0)个,(6.4±2.1) 天,(8.2±1.6)分,(7381.2±731.6)元和20.0%,两组比较差异有统计学意义(P<0.05)[治疗后研究组病人纤维蛋白原(FIB)、纤溶酶原激活剂(tPA)、纤溶酶原激活物抑制剂(PAI1)、白细胞介素10(IL10)及白细胞介素2(IL2)分别为(3.0±0.2)g/L,(24.2±3.1)ng/L,(35.9±4.2)ng/L,(157.2±23.3)pg/ml和(125.3±15.2)pg/ml,对照组分别为(3.4±0.3)g/L,(20.5±3.0)ng/L,(42.4±3.6)ng/L,(131.5±17.0)pg/ml,(142.8±17.0)pg/ml,两组比较差异有统计学意义(P<0.05)。多因素Logistic回归分析发现,病人术后复发的相关危险因素包括大隐静脉直径>1cm、左髂静脉受压、术后弹力袜穿着时间<3个月、曲张静脉团直径>2cm、静脉团处理>2次及处理闭合小隐静脉。结论  泡沫硬化剂联合EVLT治疗下肢静脉曲张疗效显著,可改善机体的凝血功能并减轻炎性反应。

关键词: 腔内激光闭合术治疗, 泡沫硬化剂, 下肢静脉曲张

Abstract: Objective To investigate the clinical effect of high ligation of great saphenous vein combined with endovenous laser closure and foam sclerotherapy in the treatment of chronic varicose veins of lower extremities.Methods  80 patients with varicose veins of lower extremities in our department were selected and divided into two groups(40 cases)according to different surgical methods.Among them,the study group was treated with high saphenous vein ligation plus foam sclerotherapy plus endovenous laser closure,and the control group(treated by high saphenous vein ligation plus endovenous laser closure).The clinical effects of the 2 groups were compared.Results  The operation time,intraoperative bleeding volume,incision number,hospitalization time,〖JP2〗visual analogue score,hospitalization expenses and complications in the study group were (57.8±13.3)min,(9.6±2.5)ml,(3.6±1.2),(4.2±1.2)d,(6.4±1.4),(6820.4±610.4)yuan,5.0%,respectively.They were significantly less than those in the control group which were (44.5±14.5)min,(15.3±4.2) ml,(7.9±2.0),(6.4±2.1) d,(8.2±1.6),(7381.2±731.6)yuan,20.0%,respectively.After treatment,FIB,tPA,PAI1,PAI1,PAI1,IL10,IL10,IL10 and IL2 of study group were (3.0±0.2)g/L,(24.2±3.1)ng/L,(35.9±4.2)ng/L,(157.2±23.3)pg/ml and(125.3±15.2)pg/ml,respectively.Which were better than control group[(3.4±0.3)g/L,(20.5±3.0)ng/L,(42.4±3.6)ng/L,(131.5±17.0)pg/ml,(142.8±17.0)pg/ml)],there were significantly improved(P<0.05).Multivariate logistic regression analysis showed that the risk factors associated with recurrence after operation included saphenous vein diameter >1cm,left iliac vein pressure,elastic socks wearing time <3months,varicose vein diameter >2cm,venous mass treatment >2 times 〖LM〗and location.Closed small saphenous vein.Conclusion Foam sclerotherapy combined with EVLT is effective in the treatment of varicose veins of lower extremities,and can improve coagulation function and reduce inflammatory reaction.

Key words: endovenous laser closure, 〓 foam sclerosing agent, 〓 varicose veins of lower extremities

[1] 符晓阳 蔡传奇 郑鸿等 . 下肢静脉曲张手术后深静脉血栓形成的原因及预防 [J]. 临床外科杂志, 2012, 20(11): 782-784.
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